I suffer from a chronic muscle problem that occasionally locks up my joints, including my wrists. It's called myofascial trigger points. I've been to doctors seeking relief but frankly, most doctors are ignorant of the condition or the solution. Also, most people don't have this as a chronic problem but only occasional problems in one area. Many people may suffer from trigger points, which feels like a charlie horse or a muscle cramp and while it may be painful, it may subside with time. Others need to treat the problem to feel relief. The treatment is a rather painful massage of the offending trigger point. You may identify the trigger point as a knot or a sore spot in a muscle. The tricky thing is, you may feel pain in your wrist but the offending muscle may be in your forearm. Since you have been examined by a doctor and treated unsuccessfully, I would certainly look at trigger points as a possible cause. Here is a web site that can help you identify the problem area and also provides information on treatment. http://myofascialtherapy.org/ Use the symptom checker to locate where the offending muscle might be. If you think this may be the problem, there are massage therapists trained in trigger point therapy and can help you release them. Once located, you can learn to massage them yourself. Hope this helps, pain sucks.