Hi! I always play Rocksmith 2014 with my interface cable, but I had some issues using others. Mine is Apogee Jam (the regular version, not 96k one) and what I did was creating a new aggregated device in MIDI Settings named "Rocksmith USB Guitar adapter" and select the Jam as Source. Then launch RS2014 as usual. I tried the same with a USB Squier Strat and while I was playing with Logic or AmpKit the guitar sounded as usual, but within RS2014 the sound was very distorted and impossible to tune. Maybe some frequency or software issues.