So after having this tone issue for a good two years, I can say that I think I have an idea of how to fix this problem. While some may say this issue is not performance related, I disagree. Alongside the tone bug I noticed that while playing that my FPS would drop while playing songs at random points in various songs. I have an older custom built PC and while it’s older it should be able to handle this game with no issues. So after playing with the Rocksmith.ini file I configured it best for my system. (This could be totally different for others depending on your machine. Read this guide for best results http://forums.ubi.com/showthread.php/802854-Rocksmith-2014-PC-Configuration-and-FAQ-Forums [Audio] EnableMicrophone=0 ExclusiveMode=1 LatencyBuffer=4 ForceDefaultPlaybackDevice=0 ForceWDM=0 ForceDirectXSink=0 Win32UltraLowLatencyMode=1 DumpAudioLog=0 MaxOutputBufferSize=0 [Renderer.Win32] ShowGamepadUI=0 ScreenWidth=1920 ScreenHeight=1080 Fullscreen=2 VisualQuality=3 RenderingWidth=0 RenderingHeight=0 EnablePostEffects=1 EnableShadows=1 EnableHighResScope=0 EnableDepthOfField=0 EnablePerPixelLighting=1 MsaaSamples=0 DisableBrowser=1 [Net] UseProxy=1 The next step may be different as well for certain users, I have an NVidia graphics card, and it will be different with for people with Radeon graphic cards and Intel integrated graphics Chips. Screenshots of my 3-D settings within the NVidia graphics http://imgur.com/a/8ZtT6 I manually configured the 3-D settings within the NVidia graphic card settings for Rocksmith by adding it to the list of games, I pretty much turned everything extra off to maximize the best possible performance. This should be possible with Radeon cards and Intel integrated graphics Chips, I would suspect the settings are very simllar. This was the key factor for me, once Rocksmith was running smooth as possible it was like playing on a different machine, I have not had the tone bug since. I played with the tone designer and session mode which pretty much always forced me to have a tone bug. I think the key factor is getting it to run as smooth as possible and the best way to do that is configuring the graphics card settings manually.