I got it working on Manjaro but latency is too high with the RT cable so I play with the microphone input through my USB Scarlett soundcard. Install winetricks if it is not installed set sound to alsa with WINEPREFIX=~/.steam/steam/steamapps/compatdata/221680/pfx winetricks sound=alsa mapping Z: to ~/.steam/steam with WINEPREFIX=~/.steam/steam/steamapps/compatdata/221680/pfx winecfg check that the route to the pfx folder is the same in your system, if not change it to match yours After the first start the rocksmith.ini file is created so you can set ExclusiveMode=0 and Win32UltraLowLatencyMode=0 This is what worked for me.