This Post is a must read for all Rocksmith players. I have been playing Rocksmith for 6 months and I have been having this issue with it not reading some notes on the 6th string. I thought it was the guitar, the strings, the software etc. BUT this post from Jimmy Page Fanboy SOLVED THE PROBLEM.After adjusting the string intonation the game experience improved greatly! Notes AND chords now are recognized. It also sounds more correct, before my playing sounded out of tune (because it WAS out of tune). Thank you much.