What's up people, while browsing around the web for a solution, I was unable to find any no-cable workaround for using an audio interface on Mac. Then I stumbled across this gem. Worked like a charm, got my M-Audio 2x2 working perfectly with Rocksmith immediately, and wanted to share for any other Mac players!   All credit to the original video creator https://www.youtube.com/watch?v=sMiHKBIjQe0