I am having issues getting my OBS/Voicemeter setup in a way that allows me to record my audio input to an OBS video, but also let me have my audio input to the game so it can keep score.  I have attached screenshots of my setup.  Can someone more experienced than me point out where I went wrong?  I am using a PreSonus AudioBox iOne, I have reinstalled the drivers.  As far as I can tell, everything is set at 48khz.  

When opening OBS, my audio input, which is et to the right source, senses no audio input.  However, under the Windows recordng devices, I can see the audio affect the meter, so I know the computer is "hearing" it.  Weird thing is, this setup as it is lets me use rocksmith with audio input.  It hears it in game.  But, voicemeter sees nothing.  The meters don't move.  I have been reluctant to change my settings, lest I lose what I do have access to.

Any help is appreciated!  

The issue I can see right away with your OBS setup is that you're trying to use A1 as your mic. You should upgrade your installation to at least Voicemeeter Banana so that you can get the output channels.

You'll want to use the B1/B2 outputs to pick up the audio in OBS.

Thank you for responding.

I followed your advice after this post and have been tweaking my settings since (like audio latency) to get everything back where it should be.  So far, I downloaded voicemeeter banana and uninstalled the vanilla version.  I downloaded RSmods and am now using it to control ASIO inputs.  Which is much easier than copy/pasting in the RS_ASIO.ini notepad.  I have gotten Rocksmith to where it'll hear my input from my Audiobox iOne, even though voicemeeter sees no input from this channel.  I have tried going through windows sound settings and changing default devices, and have tried experimenting with exclusive mode to try to get both Rocksmith and voicemeeter to hear the Audiobox at once, but I seem to be missing something.  When launching OBS (both voicemeeter and Rocksmith already running), OBS will hear the game audio through the B1 channel, but only the game audio.

I see what you mean now about using A1 for my mic.  It might help if I explained that the Audiobox device has both input channels and output channels.  On a different pc, I had somehow lucked into getting it to work the way that I want, playing the game and recording in OBS at the same time.  I even somehow had the audio from my Audiobox isolated through OBS, so I was able to just record it instead of the audio from the game along with it.  I had coppied the A1 setting over from the other computer because it had allowed me to monitor both Rocksmith audio and Audiobox audio through an amp.