Hi!
I was wondering what setup is the best for reducing audio lag and input lag.

 

My computer setup
https://imgur.com/a/xNjOLqf
 

IMHO you really should not be experiencing any lag. I have no input lag at all using the following:

 

Intel i7 3770k no OC

Nvidia GTX1060 6Gb (RS graphics maxed)

16 Gb RAM

Onboard sound.

Win 10 Pro 64 bit

 

My C: is a 450Gb SSD and my storage drives are 1 TB Seagate Hybrid drives. You system should smoke mine. 

 

I dont use the ingame instrument sounds however so I dont know if that has anything to do with it. I pretty much gave up on getting an interface to work smoothly with RS and use my pedal board. I plug my guitar into a standard cable that plugs into my tuner, then goes to a compressor/sustainer pedal, then to my MXR M80Di. The MXR has 2 outputs on it. One I plug the RT Cable into and the other goes to my Eden EC10 Amp or to the head unit depending on how badly I want to annoy the wife / neighbors.

 

The game sound I pipe out of the PC into a Techniques 7 band EQ and into a set of Mackie CR3 Creative reference monitors and a Polk Audio powered 10" Sub.