I have enjoyed Rocksmith very much for a while, so much so that I bought a bass guitar last year to play the bass tracks (well worth the $200).  Up until yesterday, I used my electric guitar for both the lead and rhythm tracks.  I had thought about using my acoustic-electric (acoustic guitar with 1/4" jack output) to play the rhythm tracks but the posts from people here who tried Rocksmith with acoustics seemed to be only moderately successful and not worth the effort.   Yesterday I plugged in m