I have a bit of tricky issue. My comp is running Ubuntu 22.04 and RS is running via Proton in Steam. I use wineasio + rs_asio with jackd2 server for low latency (got it down to < 10ms with that setup) but the problem is that this setup only works when starting Rocksmith via a WINETRICKS string outside of Steam, while Steam is running. Here is the start string:
WINEPREFIX=/home/kodi/.steam/steam/steamapps/compatdata/221680/pfx /home/kodi/.steam/steam/compatibilitytools.d/GE-Proton7-30/file