Backstory: without going into too much personal history, I've had a very on going shoulder injury and seeing a NHS physio to try and aid my shoulder back to health has made things alot worse.

I repeatedly drop things out of my hand and constantly shoulder pain, result being to play the guitar is getting harder and harder, even today I couldn't play the intro to R U Mine on the Rocksmith Championship I couldn't get out of the first minute without missing a bunch of notes, I tried Dire Dire Docks but again missed so many notes because the constant ache in my shoulder and it's had a huge knock on effect in my confidence too and my passion for playing. Even trying Bernths beginner 30 minute routine was a slog to get through. Yes I did ok in this weeks championships, but it's not good and it's not clean.

A little bit of history, I've been playing since just before the very first Rocksmith, currently I play at night (between 9pm-11pm) when the family are asleep in the summer house so I'm not distracted. I play a RGT1221PB so a good guitar.

I'm just wondering if anyone else has had similar issues?

Maybe you just need a break?

Do you work out? I´ve had a lot of shoulder problems in the past, maybe not as bad as you, but still. My physio didn´t help either.
But most of it went away when I got a TRX (google it) and started working out with that and since also starting to do more over-the-head exercises like pullups and pike pushups etc. I have even been able to relax my shoulders while playing guitar, which has been a problem for me.
But just doing some pushups everyday might help a lot.