Just got myself a brand new PC and loaded up this game and I am using a corsair virtuoso wireless headset. Game ran perfectly for the first session it was impressive running it from my headset.  Just tried tonight and I have absolutely no audio in the game, can't hear game sounds or my guitar. Did a search on the internet and tried a few fixes but nothing worked. I even plugged in an old headset into the audio jack on the computer and although I got sound from my guitar there was no audio from the game.

I am now at a total loss to sort this.

Any help much appreciated.

To whoever replied but their post disappeared I have tried every single thing that you suggested. I have given up now, tried every setting in audio settings in windows and nothing works. Think it's time to say goodbye to Rocksmith.