Is there a way to change tuning from a B to a E to save retuning guitar all the time

EOF will offer to adjust the fret number of a track's notes when you change the tuning of any string, but it won't transpose a note to another string in order to do this and will highlight the notes that you will have to manually change.  For such a big change in tuning I expect you may have to make many changes for the sake of play-ability if nothing else.