Hey guys, I've been googling and still can't find a solution and was wondering if someone here knows of a fix or a workaround. When I start Rocksmith 2014 with the Bluetooth headphones set as default device, i get a prompt that Rocksmith couldn't detect an audio output device, and there's no sound in the game.

 

The headphones in question are the Bose AE Soundlink 2.

Unless those headphones support 48kHz/16bit playback, you won't be able to get them to work with RS.

 

Note that bluetooth headphones will also add at least 30ms of latency which is a hell of a lot for a game like RS so you might not want to use them with bluetooth anyway.