Thought Guitar had loose wire or needed new jack as it would crackle and pop as i moved around..Bought a new RS cable and that cured it..My original was 4 yrs old ..Just putting this out there in case someone has something similar

After spending the last couple of months trying every possible solution I can find to improve audio quality, I am now suspecting it was the cable all along, which explains why it keeps reoccurring when I think it was fixed.

Waiting for the new one to arrive in the mail, gonna feel pretty dumb if I pulled PC apart and clean installed Windows when it was just the cable but in my defence it sounds completely different to when a regular guitar to amp cable breaks.

Still using the original 2 cables I bought with the original Rocksmith for PS3. You can repair the guitar jack end, replace the end. Soldering required though.