Is it possible to construct CDLC on a Mac (which doesn't have Windows install on it)?

 

The EOF thread has a Mac release. It has the latest release candidate, but the Mac binary doesn't get updated as often though since I only use Windows, so I have to bug the other EOF developer to build EOF for Mac.

I'm using EOF on a Mac, though I use a PC for the Wwise wav to wem file conversion, before heading back to the Mac to package using the Rocksmith Custom Toolkit.

 

It's not the most efficient process in the world.

You can install & use Wwise with wine. AFAIK the toolkit has to be run under wine as well, or else the cover art conversion won't work. There's a thread with command-line tools so you can do the Wwise conversion without having to launch the GUI, but it takes some tweaking to set up. See here & here.