Man, this is frustrating. I am working on one song and I actually got it to run once. I had to use the patcher and a window popped up and said to make sure that steam was running. I clicked ok and it ran. Yippee. Next day I do the exact same thing and the game goes to some weird place where there are no profiles and it wants me to start everything over.

 

Any ideas? I consider myself a fairly intelligent human being but this is driving me crazy.

Happens to me sometimes to. All i have to do is shut down steam and start Rocksmith (steam will start again when you do).