I should know this, but how are these played differently?  The first is obvious, but do you skip the

G string on the second?

 

l-------

l--6---

l--0---

l--3---

l-------

l-------

 

and

 

l------

l--6--

l------

l--3--

l------

l------

2 ways : 

 

Either you do finger picking with the thumb and index, if the song is meant to be played like that.

 

More commonly with a pick , you mute the middle string with the finger on the 3 lying on it without pressing it to the fret.

It can also be represented like this

6

x

3

Rocksmith tries to recognize the muted string then, and some users believe it often fails.

 

To bypass this apparent problem, some use

6

..

3

So Rocksmith only tries to recognize 6 and 3, and cares less for the muted string.

But it has to be muted.

Ah, I see.  Thank you very much TomSawyer2112.