So I see it's been over a year since the last post here but hey Rocksmith is "new to me" and I'm a lefty so I'd like to add my 2 cents. Yet another lefty here. Do all my handwriting with my left hand which is pretty of out practice these days just type everything hardly ever write anything. Anyway, I played most sports (eg basketball) right handed but tennis left handed. Played baseball left handed but never was any good. I play guitar right handed. I wonder how it would go left handed. So far I'm fine going righty on the guitar.