Finally work for me!
But I have the same issue every time I reinstall rocksmith and apply the patch without doing a clean reinstall of MacOS, the mouse gestures are not recognized;
when I move my mouse over the menu, it select the mode (like play a song, session mode...) but I can't click, and when I am in learn a song, I can't use two fingers to scroll through the songs.
Every time I reinstall Rocksmith, I delete the "Rocksmith 2014" folder into the "common" folder of steam.
Anybody else having this issue?