Okay, I see more info needed. The guitars play fine through amps, and the d string does not sound muted or dead. When I tune in RS, the program hears the d string as easily as the other strings. But when you play a song, it misses note after note after note, etc on the d string while picking up the a and g strings just fine. When strumming something with simple chords, the display is just continuously flashing blue [miss], including the open d. It does this with both guitars, in all pickup settings, nothing seems to change it much other than increasing the gain setting by about 3db, which is doubling the volume to the game. The 3db increase did reduce misses by a little, but now the guitar is getting too loud.