In my case, I always set my in-game guitar volume to 0 and play through my amp. I like having to think about how I would approximate the tone of the song outside of the game. One of the major reasons why RS is superior to learning just from tabs is that you can exactly hear what you are supposed to be playing. After intense playing for a couple of month, I get the feeling that I start to hear where my fingers are supposed to go (which is super awesome). Because of this, multitracks are not great for the purpose of learning the song. And maybe this is one reason why so many people voted for "no". I sort of agree. If you have never heard a song before, or even if you've heard, but just haven't played it much yet, then having the studio guitar track to guide you is helpful. But if you really want to be able to play the song outside of the game, then having the original guitar muted helps you to really listen to yourself and listen to the backing band for your cues. Multi-track plus no Rocksmith chart of course is even better at forcing you to learn it. We're lucky to have so many tools in the toolbox these days.