Yes I have successfully ran it on several..."outdated" and slow laptops ;) FIRST turn off any unnecessary programs running in the background of your PC including "background or hidden" then start RS, turn off all unnecessary video options (yes including the "crowd" portal) and try it, and it also sounded like you might need to "recalibrate" your guitar perhaps, turn your volume on your guitar down ever so slightly when you do this process (this wont help with the lag issue but may help with note recognition).....then when completed turn your guitar volume back to max to play (as usual) and give that a shot. hope this helps cheers